South Dakota Major Cannabis Operators

South Dakota Major Cannabis Operators — Genesis Farms, Puffy’s, FSST, Dakota Herb

SD’s licensed cannabis market is anchored by several major operators: Genesis Farms (largest state-licensed; 13–16 dispensaries), Puffy’s Dispensary (Kittrick "Kitt" Jeffries; Rapid City + Sturgis), Native Nations Cannabis (FSST Pharms LLC) (tribal; first SD medical sale July 1 2022), Dakota Herb / Big Sioux Bud (CFO Joe Stavig), The Flower Shop (Sioux Falls first), 605 Cannabis (Badlands), Greenlight Dispensary (CEO John Mueller), and Dakota Natural Solutions.

Legal Disclaimer: This information reflects South Dakota cannabis law as of June 2026 and is for educational purposes only. It is not legal advice. Laws and regulations change — always verify current rules with the South Dakota Department of Health Medical Cannabis Program or a qualified attorney. Cannabis remains illegal under federal law.

Last verified: May 2026

Genesis Farms — The Largest State-Licensed Operator

Genesis Farms is the largest state-licensed operator. COO Emmett Reistroffer leads operations. The company is vertically integrated with cultivation, manufacturing, and a network of dispensary licenses. Public materials in 2025–2026 reference "16 locations and growing", with confirmed dispensaries at:

Aberdeen (428 5th Ave NW)
Brookings (2035 Orchard Dr)
Huron (2369 Old Hwy 14)
Mitchell (716 N Rowley)
Pierre (110 W Dakota)
Rapid City (230 E North St)
Sioux Falls (3601 S Minnesota Ave)
Yankton
Vermillion (112 E Main)
Hartford (the original first state-licensed dispensary site)

KELOLAND reported 13 Genesis Farms dispensary locations statewide in mid-2025, growing toward the 16-location footprint by 2026.

Puffy’s Dispensary — Rapid City + Sturgis

Founded by Kittrick "Kitt" Jeffries (CEO) and named for his mother, Puffy’s is headquartered in Rapid City. Operations include three dispensaries (two in Rapid City + one in Sturgis), plus cultivation and manufacturing. Puffy’s won 7 of 15 Rapid City lottery licenses in 2021 but only opened three; a SD Supreme Court dispute over double-charging on unused licenses was pending in 2024–2025. Jeffries serves on the board of the Cannabis Industry Association of South Dakota (CIASD).

Native Nations Cannabis (FSST Pharms LLC) — Tribal-Owned First Sale

Tribally owned by the Flandreau Santee Sioux Tribe (FSST). Native Nations Cannabis opened the state’s first medical-cannabis dispensary on July 1, 2022 at the Royal River Casino in Flandreau, ahead of state-licensed competitors. Vertically integrated 10,000-square-foot indoor cultivation facility, commercial kitchen, and closed-loop hydrocarbon extraction lab. The tribe has reportedly issued more than 10,500 tribal medical cards and has expanded consulting partnerships to the Saint Regis Mohawk Tribe (NY), the Shinnecock Indian Nation (NY), and a 54,000-square-foot Boston, MA cultivation operation. See FSST page.

Dakota Herb / Big Sioux Bud — Sioux Falls / Brandon Vertically Integrated

Sioux Falls / Brandon-based vertically integrated operator. CFO Joe Stavig joined in June 2022; ownership includes retired SD Highway Patrol official Alan Welsh. Dispensaries in Brandon (803 9th Ave N), Aberdeen (307 7th Ave SE), Vermillion, and Huron (276 Kansas Ave SE); cultivation in Brandon and Tea.

The Flower Shop — Sioux Falls First Retail

Sioux Falls’ first retail dispensary brand; four locations: Sioux Falls (2211 W 49th St), Brookings (1004 6th St), Mitchell, and Aberdeen.

605 Cannabis (d/b/a Badlands) — Lincoln County

Lincoln County-based operator; subject of a high-profile February 2023 SDDOH product recall and subsequent litigation against the Department of Health. Two active civil cases involving 605 Cannabis executives were referenced by WeedPress in April 2026.

Greenlight Dispensary — Multistate Operator

A multi-state operator (CEO John Mueller) with three SD dispensaries. Principal financial backer of the SDBML 2024 IM 29 campaign.

Dakota Natural Solutions — Wessington Cultivator

Wessington, SD-based cultivator/supplier; supplies several SD retail brands.

Smaller Operators

Beyond the major operators above, SD’s 70–81 active retail certificates produce smaller-operator presence in:

Wagner, Tea, Brandon, Harrisburg, Worthing, Veblen, Big Stone City, Chamberlain, Colome, Flandreau (FSST), Fort Pierre, Gregory, Batesland, North Sioux City.
Plus the Pine Ridge tribal-program operators (Adonis Saltes’s No Worries dispensary plus 3+ other licensed retailers).

Vertical Integration Patterns

SD does not categorically prohibit vertical integration. Genesis Farms, Puffy’s, Dakota Herb, and FSST/Native Nations all operate vertically (cultivation + manufacturing + retail). Testing laboratories must be third-party. The vertical-integration rule allows larger operators to capture margin across the supply chain, while smaller independent retailers depend on third-party cultivators and manufacturers for inventory.